Lewy body

The pathological changes are characterized by deficiency of dopaminergic neurons in substantia nigra compacta and formation of Lewy body ( LB ) in neurons .

病理改变以黑质致密层多巴胺神经元部分缺失、神经元中有路易小体（LewyBody，LB）形成等为特点。

Objective To investigate the early characteristic diagnosis of dementia with Lewy body ( DLB ) .

目的探讨路易体痴呆（dementiawithLewybody，DLB）的早期诊断。

Objective To investigate the pathological features of Lewy body disease .

目的为探讨Lewy小体病的病理特点，报道1例80岁，女性，以进行性痴呆、肌肉强直为特征，病理学上确认为Lewy小体病的国人尸体解剖病例。

The study of β A 4 expression in brain tissue in diffuse Lewy body disease

βA4在弥漫性Lewy体病脑组织表达的研究

Clinicopathological study on Lewy body disease

Lewy小体病的临床病理学研究

The roles of proteasome on nigral degeneration and Lewy body formation

蛋白酶体在脑黑质变性和Lewy小体形成中的作用

The diagnosis of dementia with Lewy body

路易体痴呆的诊断

Anosmia is very common in the Lewy body variant of Alzheimer 's disease

嗅觉缺失最常见于Lewy体型阿尔茨海默病患者

Lewy body Parkinson 's disease in a large pedigree with 77 Parkin mutation carriers

Lewy小体帕金森病在一个有77例Pakin基因突变携带者大家系中的发病情况

Nigral degeneration and Lewy body were viewed by HE staining ;

HE染色观察黑质变性和Lewy小体形态；

Clinical and ~ 1H-magnetic Resonace Spectroscopy Analysis on Alzheimer 's Disease and Dementia with Lewy Body

阿尔茨海默病和路易体痴呆的临床和~1H-MRS分析

Objective To set up the Parkinson 's disease ( PD ) rat model with pathologic characteristic of Lewy body in nigral cells .

目的建立符合帕金森病（PD）病理特征&黑质细胞有Lewy体的PD大鼠模型。

Some of nigral cells contained acidophilic Lewy body with intense immune response to α - synuclein ;

部分细胞胞质内出现αsynuclein免疫反应呈强阳性的Lewy小体；

Cognitive differences in dementia patients with autopsy-verified AD , Lewy body patho-logy , or both

尸检证实阿尔茨海默病、Lewy体病或两者兼有的痴呆患者的认知功能差异

Applying Lactacystin , a selective proteasome inhibitor , to set up the rat model of Parkinson 's disease with Lewy body

应用蛋白酶体抑制剂Lactacystin建立有Lewy体的帕金森病大鼠模型

METHODS : Pathological changes and clinical manifestation of dementia with Lewy body were analyzed as well as its treatment and prognosis through the review of literatures .

方法：复习文献，分析路易体痴呆患者的病理改变和临床表现特点，了解其治疗和预后。

The expression of alpha-synuclein in double factors group was significantly increased compared to NS group and most of nigral cells in double factors group showed Lewy body .

双因素组黑质细胞α-synuclein的表达较NS组显著增高，多数细胞内出现α-synuclein免疫反应呈强阳性的Lewy小体。

Conclusion The rat model of Parkinson 's disease with Lewy body is set up by using Lactacystin which can block the α - synuclein degradation .

结论利用蛋白酶体抑制剂Lactacystin阻碍α-synuclein的降解可以建立有Lewy体的PD大鼠模型。

Presence of ApoE ε 2 allele may be a genetic factor of differentiation between Lewy body disease ( LBD ) and late onset AD.

ApoEε2可能是区别LewyBody病和晚发AD的遗传因素之一。

Impaired myocardial ~ ( 123 ) I-metaiodobenzylguanidine uptake in Lewy body disease : Comparison between dementia with Lewy bodies and Parkinson 's disease

Lewy体病患者损伤心肌对~（123）I-间碘苄胍的摄取情况：Lewy体型痴呆和帕金森病的比较

Conclusions The decrease of hippocampus NAA / Cr ratios of patients with Alzheimer 's disease and dementia with Lewy body might be helpful for their early diagnosis and effective treatment .

结论患者海马NAA/Cr值降低能为阿尔茨海默病和路易体痴呆的早期诊断提供有价值的信息，有效指导临床治疗。

Objective To observe β A 4 expression in diffuse Lewy body disease ( DLBD ) and investigate the relationship between β A 4 expression on neuron degeneration and loss .

目的观察βA4在弥漫性Lewy体病（DLBD）脑组织中的表达，探讨βA4表达与神经元变性、缺失的关系。

PD rats that expressed Lewy body and presented lateral rotation were made by injecting 8 μ g lactacystin into one side of substantia nigra compact part of rat with stereotaxic technique .

在大鼠单侧黑质致密部（SNc）立体定向注射蛋白酶体抑制剂lactacystin8μg，建立表达Lewy小体并向偏侧旋转的PD大鼠。

AIM : Dementia with Lewy body has ranked the second in the incidence of dementia , only inferior to Alzheimer disease , accounting for 15 % to 25 % of all dementia patients .

目的：路易体痴呆的发病率是仅次于阿尔茨海默病的第2位痴呆症，约占痴呆患者的15%～25%。

Weeks later the number of TH positive cells were decreased by 83.29 % compared with NS group ( P < 0.01 ), some of which contained Lewy body with intense immune response to α - synuclein .

给药后3周黑质部TH阳性细胞数较NS组减少了83.29%（P<0.01），部分黑质细胞内出现α-synuclein免疫反应呈强阳性的Lewy体；

Weeks later , nigral degeneration were present in 2 μ g and 8 μ g groups ; some of nigral cells contained acidophilic Lewy body with intense immune response to α synuclein ;

给药后3周，病理检查发现2μg和8μg组大鼠黑质变性，部分黑质细胞内出现αsynuclein免疫反应呈强阳性的嗜酸性包涵体；

Objective To analyze the clinical manifestations and () ~ 1H-magnetic resonace spectroscopy ( ~ 1H-MRS ) examinations of Alzheimer 's disease and dementia with Lewy Body , and further provide evidence for early diagnosis , differential diagnosis and treatment .

目的对轻、中度阿尔茨海默病和路易体痴呆患者进行临床表现和1H-MRS研究，以期对疾病的早期诊断、鉴别诊断和治疗有所帮助。

Pathological changes are dopaminergic neurons degeneration and apoptosis of the nigrostriatal area in the midbrain and the formation of lewy small body .

病理改变为中脑黑质纹状体区多巴胺能神经元变性凋亡和lewy小体形成为特征。